Correction: Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice

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Correction: Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice

[This corrects the article DOI: 10.1371/journal.pone.0160431.].

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Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice

OBJECTIVE Obesity increases morbidity and resource utilization in sepsis patients. Sepsis transitions from early/hyper-inflammatory to late/hypo-inflammatory phase. Majority of sepsis-mortality occurs during the late sepsis; no therapies exist to treat late sepsis. In lean mice, we have shown that sirtuins (SIRTs) modulate this transition. Here, we investigated the role of sirtuins, especially ...

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Sirtuin 2 Regulates Microvascular Inflammation during Sepsis

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2016

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0162560